Due to auto-antibodies against complex of heparin and platelet factor 4.Little clinical significance, self-resolves.Due to direct platelet-aggregating effect of heparin.Warfarin: increased INR due to changes in pharmacodynamics of warfarin.Release of lipoprotein lipase from tissues, accelerating clearing of post-prandial lipaemia.Heparin, itself, is a naturally occurring substance that the human body produces in varying quantities in both the. Lovenox has a lower molecular weight which means that it will stay in a woman’s body much longer than heparin would, as much as 24 hours in some cases. Bleeding (risk increased in elderly women and renal failure) However, the lovenox mechanism of action is different than that of heparin.Heparin Induced Thrombocytopenia (see below).Excess protamine must be avoided as it also has an anticoagulant effect.For every 100 units of heparin remaining in patient, administer 1mg protamine IV.Administration of antagonist protamine sulfate.Close monitoring of aPTT is necessary in patients receiving UFH infusions.
Continuous (following bolus) or intermittent.Acts as a co-factor without being consumed.Heparin binds to and causes a conformational change of ATIII, exposing its active site for more rapid interaction with proteases and accelerating inhibition reactions 1000-fold.Antithrombin III (ATIII) normally inhibits clotting factor proteases, especially IIa (thrombin), IXa, and Xa, by forming equimolar stable complexes with them.Indirect thrombin inhibitor that acts as a co-factor for the antithrombin-protease reaction:.
0 kommentar(er)
